Potential Clinical & Surgical Applications in Regenerative Medicine

Author: Orca Health

September 14, 2020

The study of Regenerative Medicine and resulting clinical therapies have the potential to transform medicine and surgery. Progress that spans the spectrum of discovery science, translational research, and clinical applications harnesses the power of regenerative products and therapies to supplement and assist in the body’s natural regenerative functions. The ability to aid in the repair of injured, diseased, or congenitally defective tissues is a vital innovation across medical specialties. 

The following information presents a brief overview of potential clinical and surgical applications in regenerative medicine.

Burns (All Anatomical Areas for 2nd & 3rd Degree)

Burn treatment is evolving with the advancement of regenerative medicine therapies. In severe burns (2nd and 3rd degree) both the dermal and epidermal layers are damaged and alternative cell-based treatments are revolutionizing the healing process. The regenerative capability of current therapies is to assist with the natural repair and restoration of the burned tissue to its original physiological function. 

Gastrointestinal (Fistulas, Strictures, etc.)

The gastrointestinal (GI) tract is an incredibly complex structure involving many organs. Regenerative products aim to help the natural process of organ repair, reduce surgical complications, and improve the quality of life of patients post-treatment. Biotechnology applies to GI conditions including inflammatory bowel disease, cancer, organ transplant, fistulas, etc. 

Neuropathy (Nerves, etc.)

The nervous system is a complex network of delicate structures that are complicated for the body to naturally regenerate and heal when damaged. Current regenerative therapies are designed to help with the natural repair of these nervous tissues and nerve connections. This is especially significant for those who suffer from neuropathy where current treatments include pain, anti-depressant, and anti-seizure medications, physical therapy, and/or surgery.  

Ocular (Dry Eye, GVHD, PRK Ocular Surface Injuries, etc.)

The biologics used for ocular conditions aim to help the natural regeneration process for affected tissues, restrict disease and scar tissue progression, and maintain optimum ocular health. These biologic strategies provide a new perspective in the management of eye conditions including dry eye, retinal and corneal diseases, glaucoma, and ocular cancer. 

 

Condition: Dry Eye 

Orthopedics (Carpal Tunnel, Joints, Muscle Tears, Tendonitis, Tendon Tears, etc.) 

Orthopedics has witnessed significant strides in the field of biologic drug development. The products offered in clinical and surgical applications aim to help with a wide range of musculoskeletal conditions including the natural repair of damaged tissues (tendons, ligaments, muscles, and joints), relief of arthritic symptoms and slow the progression of tissue loss (ex. Cartilage and meniscus). 

 

Carpal Tunnel Injection

Spine (Cervical, Lumbar, Sacral, Thoracic, etc.)

Regenerative therapies and products can help individuals dealing with spine-related injuries and diseases. These therapies help improve current treatment options and delay or potentially avoid surgical intervention. The new biological strategies for treating the affected spine aim to be a beneficial, nonsurgical solution to the numerous conditions causing back pain.

 

Thoracic Facet Injection

Plastic Surgery

Plastic surgery involves the alteration or reconstruction of body tissue to either improve function or aesthetics. Therefore, regenerative strategies are crucial for the advancement of this field and the delicate treatment of patients. Regenerative treatments aim to enhance the natural tissue healing process and augment current treatment options. 

Temporomandibular (TMJ Joint Arthritis, etc.)

Temporomandibular joint (TMJ) conditions are common and often very painful but currently have limited therapeutic options. Biotechnology is crucial for TMJ repair because its limited healing capacity makes natural tissue regeneration difficult. Innovation in regenerative therapies aims to provide new strategies for treatment, healing, and to improve the quality of life in patients. 

Urology (Peyronies, Urethral Stricture, etc.)

The field of urology encompasses the urinary tract and male reproductive organs. Conditions affecting these tissues, organs, and processes are highly critical for patients. Biologics aim to help the natural processes of repair and tissue regeneration to improve current treatment options. 

Wounds (Acute, Chronic, Necrotizing Fasciitis, Ulcers, etc.)

Wound healing is a primary focus of regenerative medicine because its natural processes already involve regeneration, replacement, and rejuvenation of the skin. However, many clinical wound care processes are simply ineffective and costly. Regenerative products aim to accelerate the natural wound healing process and restoration of skin tissue and structure. 

Orca Biotech provides premium regenerative products that help to advance innovative treatments across medical specialties. We strive for regenerative excellence through industry and academic collaboration. Our products are accompanied by multiple IND and IRB submissions for use in a variety of clinical applications. 

References

Cheng, J, Farrokhi, A, Jalili, R. “Therapeutic Use of Stem Cells in Treatment of Burn Injuries.” 2018, Journal of Burn Care & Research: Official Publication of the American Burn Association. https://www.semanticscholar.org/paper/Therapeutic-Use-of-Stem-Cells-in-Treatment-of-Burn-Cheng-Farrokhi/acb5d30984aec796447c2cd59c64ada9a2fd2bfb

Li, Z. Maitz P. “Cell Therapy in Severe Burns” 2018, Burns and Trauma: Oxford University Press. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971426/

Bitar, K., Zakhem, E. “Bioengineering the gut: future prospects of Regenerative Medicine.” 2016 Nature Reviews Gastroenterology and Hepatology https://www.nature.com/articles/nrgastro.2016.124

Genus, T., Packer C., Simpson, S. “Regenerative Medicine for Gastrointestinal Diseases.” 2016 Horizon Scanning Research and Intelligence Centre: University of Birmingham. https://www.researchgate.net/publication/315386152_Regenerative_medicine_for_gastrointestinal_diseases

Terzic, A. Toman, B. “Neuroregenerative Medicine”. Mayo Clinic Center for Regenerative Medicine. https://www.mayo.edu/research/centers-programs/center-regenerative-medicine/focus-areas/neuroregeneration

Villatoro, A., Fernandez, V., Claros, et. al. “Regenerative Therapies in Dry Eye Disease: From Growth Factors to Cell Therapy.” 2017. International Journal of Molecular Science. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713234/

Van Bellinghen, X., Idoux-Gillet, Y. , et al. “Temporomandibular Joint Regenerative Medicine.” 2018. International Journal of Molecular Science. https://www.ncbi.nlm.nih.gov/pubmed/29393880

Vapniarsky, N. Huwe, L., et. al. “Tissue engineering toward temporomandibular joint disc regeneration.” 2018. Science Translational Medicine. https://stm.sciencemag.org/content/10/446/eaaq1802.full